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The Cathedral of the Holy Cross is the cathedral of the Roman Catholic Archdiocese of Boston and is the largest Roman Catholic church in New England.When construction was finished, the cathedral rivaled both Old South Church and Trinity Church in grandeur, signalling the emergence of Roman Catholics in what was, at the time of construction, a largely Protestant city and state.The cathedral is located in the city's South End neighborhood, at 1400 Washington St. Although the South End was initially developed for Boston's emerging Anglo-Saxon Protestant middle class, the neighborhood transitioned to new immigrants, especially Irish, as middle class owners moved to the new Back Bay neighborhood.The cathedral functions both as a cathedral and as a parish. The Cathedral Parish consists of large English- and Spanish-speaking congregations, drawn largely from the local area, and also includes three Archdiocese-wide congregations: the Ge'ez Rite practiced by Ethiopian, Eritrean, and Egyptian Catholics; the German Apostolate; and the Tridentine Rite Catholic community. The first of these congregations moved to the cathedral from the nearby Holy Trinity Catholic Church in 1994, the other two in 2008.

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